Anthropic Says Claude Mythos Got Claude Running on AMD GPUs in Three Days

Nov 11, 2026
Anthropic says Claude Mythos got Claude processing prompts on AMD MI355X GPUs in about three days, work that used to take dozens of engineers six to 12 months.

Anthropic says its Claude Mythos model got Claude processing prompts on AMD MI355X GPUs in about three days with almost no human help, OfficeChai reports from Anthropic's IPO roadshow video. According to the company, Claude wrote or adapted almost all the specialized GPU code needed, and the same job used to take dozens of engineers six to 12 months.

An Anthropic executive said in the video that the company trains and serves Claude across all four major chip families. The executive said this lets Anthropic pursue the best price performance in a supply constrained market and match each chip to the work it suits best, with the goal of treating all its chips as one pool of compute. This year was the first time Anthropic worked with AMD GPUs.

The bring up follows an agreement for Anthropic to deploy up to 2 gigawatts of AMD Instinct MI450 series chips. AMD agreed to invest up to $5 billion in Anthropic as deployment milestones are reached, and Claude will help optimize AMD's ROCm software.

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