XtalPi and DoveTree Form $6 Billion AI Drug Discovery Partnership

August 08, 2025
XtalPi and DoveTree Medicines have announced a strategic collaboration worth up to $6 billion to leverage AI and robotics in drug discovery, focusing on oncology, immunology, and other therapeutic areas.
XtalPi and DoveTree Form $6 Billion AI Drug Discovery Partnership

XtalPi and DoveTree Medicines have announced a landmark collaboration valued at up to $6 billion, announced in a press release. This strategic partnership aims to harness artificial intelligence and robotics to develop novel therapeutics across various fields, including oncology, immunology, inflammation, neurology, and metabolic diseases.

Under the agreement, DoveTree will have exclusive global rights to develop and commercialize a portfolio of innovative therapeutics generated through the partnership. XtalPi has received an upfront payment of $51 million and stands to gain an additional $49 million in near-term payments, along with development and commercial milestones and tiered royalties totaling up to $5.89 billion.

The collaboration combines XtalPi's advanced drug discovery platform with DoveTree's expertise in biological research, focusing on first-in-class candidates for diseases with significant unmet needs. The partnership will also explore emerging modalities like molecular glue, aiming to tackle historically challenging mechanisms.

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