Clairyon AI Agent Shown to Improve Sepsis Care Compliance in JAMA Study

Jun 26, 2026
A study published in JAMA Network Open found that Clairyon's AI Clinical Abstraction Agent improved SEP-1 sepsis care compliance by 13 percent across two emergency departments.

Clairyon announced the results of a cluster randomized study published in JAMA Network Open, according to a press release. The research evaluated Clairyon's Clinical Abstraction Agent, which uses large language models to automate quality reporting for severe sepsis and septic shock (SEP-1) measures.

The study was conducted at two academic emergency departments and compared AI-assisted reporting to standard manual review. Hospitals using Clairyon's system achieved an absolute 13 percent improvement in SEP-1 compliance, rising from 70.1 percent to 82.9 percent. The AI agent reached a 92 percent agreement rate with expert human reviewers.

By automating chart abstraction and providing near real time feedback, the system reduced the administrative workload associated with quality reporting. The study was supported through a Small Business Innovation Research grant from the National Library of Medicine.

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